Prostate Cancer Screening

The prostate releases the prostate-specific antigen, or PSA. Small amounts of PSA ordinarily circulate in the bloodstream and can be measured by a PSA test to monitor the health of the prostate. A PSA test is a simple blood test and can be done at any blood testing laboratory or by your doctor.

The PSA test is a good screening tool but by itself does not indicate if there a person has prostate cancer or not!

PSA Test: What is Normal?1

PSA tests produce results measured by nanograms of PSA per milliliter of blood (ng/ml).

Most physicians consider a PSA level of 4 ng/ml or higher an indicator that further diagnostics should be performed – a score of 4 ng/ml or above typically means there is a 25% chance that a patient is being diagnosed with prostate cancer. Scores of 10 ng/ml or above typically mean there is a 50% chance of being diagnosed with prostate cancer.  

Some doctors will lower the cutoff for further diagnosis to 2.5 or 3 ng/ml, however, doctors largely agree that a score lower than 2.5 ng/ml does not need further examination.

It is important to note that PSA levels can rise naturally with age, and that a number of benign (not cancerous) conditions can also affect PSA levels, such as prostatitis (inflammation of the prostate), benign prostatic hyperplasia (BPH, enlarged prostate), urinary tract infection (UTI), or even injury to the prostate. Other factors such as sexual activity right before testing can impact the PSA levels as well, so it is essential to consult a doctor regarding the meaning and next steps of your PSA testing results.

Doctors will frequently ask patients to repeat a PSA test if the first test result was high, to exclude external factors that may be impacting the PSA results. 

The HALO Dx Approach – PSA Density

PSA testing is typically the first step in screening for prostate cancer, however the PSA screening by itself does not indicate if cancer is present.

To increase the efficacy of PSA interpretation, at HALO Dx we use PSA Density  instead. PSA levels are higher in men with larger prostate glands. The PSA density (PSAD) adjusts for that. The doctor measures the volume (size) of the prostate gland with an ultrasound and divides the PSA number by the prostate volume.

Interview with Dick Ablin, the discoverer of PSA, lead by HALO Dx’ Bernadette Greenwood:

Where Can I Get PSA Testing?

Consult with your general practitioner or urologist about receiving a PSA test in their offices. PSA tests are typically covered by Medicare once a year for men 50 years and older, and there is no co-pay or deductible needed. However, additional PSA test costs may need to be covered by the patient. Many states now have laws which require private health insurers to cover the costs for PSA testing.

For those without insurance or with insurance that does not cover PSA testing, free tools are available through advocacy groups, such as ZERO.

ZERO National Free Testing Map

Companies such as ImAware also offer take-home PSA testing kits and telemedicine appointments to discuss PSA results with a physician.


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