Improved Prostate Cancer Screening with mpMRI

We use multiparametric magnetic resonance imaging (mpMRI)—combined with PSA testing—for to help improve the accuracy of prostate cancer screening.

The American Urologic Association (AUA) now recommends mpMRI along with a PSA test prior to any biopsy. mpMRI can not only detect prostate cancer more accurately than other tests, it can differentiate between aggressive and slow growing cancers. This can help you avoid an unnecessary biopsy.

If a biopsy is needed, mpMRI can be used to more precisely guide the biopsy, ensuring that sampling is not “blind”—randomly taken from across the gland—which may completely miss the disease.

mpMRI: A clinically proven innovation

Multiparametric magnetic resonance imaging (mpMRI) is a powerful tool used to identify areas of the prostate that might be suspicious for clinically significant cancer. mpMRI is based on well-established MRI scanning technology and provides a detailed image of the prostate.

mpMRI provides a more holistic view of the prostate compared with more traditional approaches. While only a biopsy can diagnose cancer, mpMRI can assist with the characterization of areas within the gland that may warrant biopsy. Given the utility of mpMRI, the AUA recommends mpMRI for men with high PSA and BEFORE biopsy in their most recent policy statement.

mpMRI uses three different types of images to see inside the prostate gland. The first are T1- and T2-weighted imaging which show the anatomy of the gland. Second is diffusion- weighted imaging (DWI) which identifies areas where motion of water molecules is restricted due to cancer tissue, and the third is dynamic contrast enhanced imaging (DCE) which uses gadolinium-based contrast to find areas where new blood vessels are growing (cancer cells make their own blood vessels to supply themselves with oxygen and nutrients). All of these images are sent to a computer workstation to aid the radiologist in interpreting the images with the goal of finding tumor-suspicious regions. This is called Computer Aided Detection (CAD).


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