PSMA PET Imaging Test Spots Prostate Cancer in Lymph Nodes

Results of a phase 3 clinical trial are moving the ball closer to the goal in the field of PSMA PET imaging.

Progress continues in the field of PSMA PET imaging for men with intermediate- or high-risk prostate cancer.

Doctors at UCSF and UCLA report results of a phase 3 clinical trial evaluating the efficacy of 68Ga-PSMA-11 and positron emission tomography (PET) imaging.[i]

Similar to the imaging agent PYLARIFY® used by HALO Diagnostics’ PET technicians, 68Ga-PSMA-11 is an injectable contrasting agent that targets prostate-specific membrane antigen (PSMA), a protein found on the surface of more than 90% of prostate cancer cells.

The study, reported in JAMA Oncology, showed the PET scans had a sensitivity of 40% for detecting the spread of disease into lymph nodes inside and outside the pelvis. The results were confirmed by lymph node biopsy.

The test demonstrated a 95% specificity in detecting which patients in the study did not have nodal metastases.

The PSMA PET scan using 68Ga-PSMA-11 is only available at UCSF and UCLA.

Earlier this year, the National Comprehensive Cancer Network (NCCN) made PYLARIFY (18F-DCFPyl) part of their guidelines on prostate cancer screening and early detection. It is available for use with a HALO Diagnostics PET scan.

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Article references:

[i] Hope TA, Eiber M, Armstrong WR, et al. Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node DissectionA Multicenter Prospective Phase 3 Imaging TrialJAMA Oncol. Published online September 16, 2021. doi:10.1001/jamaoncol.2021.3771

 


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